Sulindac Sulfone-d6

Sulindac Sulfone-d6 is the deuterium labeled Sulindac sulfone. Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research[1].

2519512-94-6

12352005

Drug Metabolite; Isotope-Labeled Compounds; mTOR

Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR

Cancer

FC1=CC=C2C(C(C([2H])(C(O)=O)[2H])=C(/C2=C(C3=CC=C(C=C3)S(=O)(C([2H])([2H])[2H])=O)\[2H])C)=C1

C20H11D6FO4S

378.45

[1]Aono Y, et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun. 2018 Nov 10;505 (4) :1203-1210.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W742805/

Isotope-Labeled Compounds

No Development Reported