SYK (fosfo Tyr352) Antilichaam

Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion

6850

P43405

NP_001167638.1

Human, Mouse, Rat

SYK (phospho Tyr352) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 352 (S-P-Y (p) -A-D) derived from Human SYK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

72 kDa

IgG

The antibody detects endogenous levels of SYK only when phosphorylated at tyrosine 352.

Western Blot: 1:500~1:1000

SYK

Spleen tyrosine kinase

Homo sapiens

Yagi S., Biochem. Biophys. Res. Commun. 200:28-34 (1994) .

Law C.-L., J. Biol. Chem. 269:12310-12319 (1994) .

SYK, KSYK, FLJ25043, FLJ37489

WB

21361553

Liquid