SYK-remmer, R406
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC₅₀ = 41 nM). R406 strongly inhibits SYK but not Lyn, and displays 5-fold less potency towards FLT3. R406 induces apoptosis in diffuse large B-cell lymphoma cell lines. It blocks B cell receptor signaling through inhibition of SYK autophosphorylation of Y525/Y526 and SYK-dependent phosphorylation of the B-cell linker protein.
gel pack
-20°C
36 months
Beschrijving
R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC₅₀ = 41 nM). R406 strongly inhibits SYK but not Lyn, and displays 5-fold less potency towards FLT3. R
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