SYNGR1 Antilichaam

SYNGR1 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. The gene for SYNGR1is located at chromosome 22q13, a region linked to schizophrenia; however, there is mixed evidence suggesting that mutations in SYNGR1 might be associated with schizophrenia.

9145

O43759

CAA05322

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

SYNGR1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

SYNGR1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SYNGR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SYNGR1

Synaptogyrin 1

Homo sapiens

Kedra D, Pan HQ, Seroussi E, et al. Characterization of the human synaptogyrin gene family. Hum. Genet.1998; 103:131-41.

Egaña LA, Cuevas RA, Baust TB, et al. Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J. Neurosci.2009; 29:4592-604.

Cheng MC and Chen CH. Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia. J. Psychiatr. Res.2007; 41:1027-31.

Wang Y, Yu L, Zhao T, et al. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. Psychiatry Res.2009; 169:167-8.

SYNGR1 Antibody: Synaptogyrin-1

ELISA, WB, IHC-P, IF

2959866

Liquid