SYNPO Antilichaam

SYNPO Antibody: SYNPO, also known as synaptopodin, is an actin-associated protein in telencephalic dendrites and renal podocytes. SYNPO is tightly associated with the dendritic spine apparatus, and mice lacking the SYNPO gene lack the apparatus. These SYNPO-null mice also demonstrate an impaired ability to express long-term potentiation as well as deficits in spatial memory tasks, indicating that SYNPO is involved in the regulation of synaptic plasticity. Recent studies suggest that SYNPO is linked to neuronal calcium stores and plays a role in the calcium store-associated ability of neurons to undergo long-term plasticity.

11346

Q8N3V7

NP_001159680

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

SYNPO Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

SYNPO Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SYNPO antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of SYNPO are known to exist; this antibody will detect all three isoforms. SYNPO antibody is predicted to not cross-react with other SYNPO family member proteins.

SYNPO

Cat. No. 10-301 - Human Brain Tissue Slide

Synaptopodin

Homo sapiens

Mundel P, Heid HW, Mundel TM, et al. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J. Cell Biol. 1997; 139:193-204.

Deller T, Merten T, Roth SU, et al. Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. J. Compl. Neurol. 2000; 418:164-81.

Deller T, Korte M, Chabanis S, et al. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc. Natl. Acad. Sci. USA 2003; 100:10494-9.

Jedlicka P, Schwarzacher SW, Winkels R, et al. Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus 2009; 19:130-40.

SYNPO Antibody: KIAA1029, Synaptopodin

ELISA, WB, IHC-P, IF

261278297

Liquid