T-1032 (vrije basis)

T-1032 free base is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. T-1032 free base shows relaxant effect on isolated rabbit corpus cavernosum. T-1032 free base can be used for the research of erectile dysfunction[1].

212500-02-2

12352005

Phosphodiesterase (PDE)

Metabolic Enzyme/Protease

Others

O=C(N(C(C(OC)=O)=C1C2=CC(OC)=C(C(OC)=C2)OC)C3=CC=C(C=C3)N)C4=C1C=CC(OCC5=CC=CC=N5)=C4

C32H29N3O7

567.59

[1]Ukita T, et al. Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives. J Med Chem. 2001 Jun 21;44 (13) :2204-18.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W705784/

Reference compound1

No Development Reported

PDE5