T-cadherine-antilichaam

T-cadherin Antibody: T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth. T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage. T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers. Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation.

1012

P55290

P55290.1

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

T-cadherin Antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (93%)

T-cadherin Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

T-cadherin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of T-cadherin are known to exist.

CDH13

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 17-004 - K-562 Cell Slide

Cat. No. 17-201 - 3T3/BALB Cell Slide

Cadherin 13

Homo sapiens

Ranscht B and Dours-Zimmerman MT. T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron 1991; 7:391-402.

Ivanov DB, Philippova MP, and Tkachuk VA. Structure and functions of classical cadherins Biochemistry (Moscow) 2001; 66:1175-66.

Takeuchi T, Misaki A, Chen BK, et al. H-cadherin expression in breast cancer. Histopathology 1999; 35:87-88.

Sato M, Mori Y, Sakurada A, et al. The H-cadherin (CDH13) gene is inactivated in human lung cancer. Hum. Gen. 1998; 103:96-101.

T-cadherin Antibody: Cadherin-13, Heart cadherin, H-cadherin, P105, Truncated cadherin, T-cad, T-cadherin

ELISA, WB, IHC-P, IF

1705552

Liquid