TAB3 Antilichaam

TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

257397

Q8N5C8

NP_690000

Human

Unconjugated

Primary Antibodies

Autophagy

TAB3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 10-401 - Human Kidney Tissue Slide

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (92%)

TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TAB3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.

TAB3

TGF-beta activated kinase 1/MAP3K7 binding protein 3

Homo sapiens

Cheung PC, Nebreda AR, and Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004; 378:27-34.

Besse A, Lamothe B, Campos AD, et al. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J. Biol. Chem. 2007; 282:3918-28.

Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.

TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3

ELISA, IHC-P

98991767

Liquid