TACI Recombinant eiwit

TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells) . TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.

23495

O14836

NP_036584.1

Recombinant Proteins

E. coli

Apoptosis, Immunology

Room Temp

The lyophilized TACI recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TACI is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TACI recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Tumor necrosis factor receptor superfamily, member 13B

Homo sapiens

CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor

Human

6912694

Lyophilized