TACSTD2-eiwit (C-His, Cynomolgus, Rhesus)

TACSTD2

C-His

< 1.0 EU per μg protein as determined by the LAL method.

≥ 95 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.

1.Loaded Anti-TROP2 (Research Grade Sacituzumab Biosimilar) on ProA Biosensor, can bind Recombinant Cynomolgus/Rhesus TROP2 Protein, His Tag (Cat. No. 90893-C08H) with an affinity constant of 1.53 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested) . 2.Immobilized Anti-TROP2 (Research Grade Sacituzumab Biosimilar) at 2μg/mL (100μL/well) can bind Recombinant Rhesus / Cynomolgus TROP2 Protein (His Tag) (Cat: 90893-C08H), the EC50 is 1.3-3.9 ng/mL (Routinely tested) . 3.Anti-TROP2 (Research Grade Datopotamab Biosimilar) captured on CM5 chip via Anti-Human IgG Fc, can bind Recombinant Rhesus / Cynomolgus TROP2 Protein (His Tag) (Cat: 90893-C08H) with an affinity constant of 13.000 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) . 4.Immobilized Recombinant Rhesus / Cynomolgus TROP2 Protein (His Tag) (Cat: 90893-C08H) at 1 μg/mL (100 μL/well) can bind Anti-TROP2 (Research Grade Datopotamab Biosimilar), the EC50 is 0.6-1.8 ng/mL (QC tested) .

Met1-Arg272

The recombinant Rhesus/Cynomolgus TACSTD2 consists of 253 amino acids and predicts a molecular mass of 28.7 kDa. As a result of glycosylation, it migrates as an approximately 44.6 kDa band in SDS-PAGE under reducing conditions.

Cynomolgus, Rhesus