TAK1 Antilichaam

TAK1 Antibody: TAK1 (TGF-beta activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7) . It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3. Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation, while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity.

6885

O43318

BAA25025

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Cancer

TAK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1471 - Rat Thymus Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

TAK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TAK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

MAP3K7

Mitogen-activated protein kinase kinase kinase 7

Homo sapiens

Yamaguchi K, Shirakabe K, Shibuya H, et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 1995; 270:2008-11.

Irie T, Muta T, and Takeshige K. TAK1 mediates an activation signal from toll-like receptor (s) to nuclear factor-κ B in lipopolysaccharide-stimulated macrophages. FEBS Lett. 2000; 467:160-4.

Akira S and Takeda K. Toll-like receptor Signalling. Nat. Rev. Immunol. 2004; 4:499-511.

Jiang Z, Ninomiya-Tsuji J, Qian Y, et al. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol. Cell Biol. 2002; 22:7158-67.

TAK1 Antibody: TAK1, MEKK7, TGF1a, TAK1, Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1

ELISA, WB, IF

2924624

Liquid