Tamnorzatinib (ONO-7475)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1646839-59-9
C13795-5mg
Axl
Protein Tyrosine Kinase
COC1=CC2=C (C=CN=C2C=C1OC) OC3=CN=C (C=C3) NC (=O) C4=CC5=C (CCCC5=O) N (C4=O) C6=CC=CC=C6
C32H26N4O6
Tamnorzatinib (ONO-7475) is a potent, selective, and orally active novel inhibitor of Anexelekto (Axl) /MER tyrosine kinase with IC50 of 0.7 nM and 1.0 nM for AXL and MER, respectively. ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells. ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells.
3 years -20°C powder
Beschrijving
Tamnorzatinib (ONO-7475) Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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