Tamoxifen-13C6

Tamoxifen-13C6 (ICI 47699-13C6) is the 13C-labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[5]. Tamoxifen activates autophagy and induces apoptosis[4]. Tamoxifen also can induce gene knockout of CreER transgenic mouse[6].

1346606-38-9

ICI 47699-13C6; (Z) -Tamoxifen-13C6; trans-Tamoxifen-13C6

12352005

Apoptosis; Autophagy; Estrogen Receptor/ERR; HSP; Isotope-Labeled Compounds

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Metabolism-protein/nucleotide metabolism

Endocrinology

[H][13C]1=[13CH][13CH]=[13C](/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)[13CH]=[13CH]1

C20 13C6H29NO

377.47

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W778408/

Isotope-Labeled Compounds

No Development Reported