TAPBP Antilichaam

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

6892

O15533

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 30-260 of human TAPBP (NP_757345.2) .

Unconjugated

Primary Antibodies

Immunology, Signal Transduction

Affinity purification

THP-1

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 48kDa

IgG

TAPBP

Raji

M21

Mouse liver

TAP binding protein (tapasin)

Homo sapiens

TAPBP, NGS17, TAPA, TPN, TPSN

WB, IHC, IF

Liquid