Tat-IKIP (46-60) (TFA)

Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60). Tat-IKIP (46-60) is a IκB kinase (IKK) -targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282) -induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis[1][2].

12352209

IKK; NF-κB

NF-κB

Inflammation/Immunology

99.76

O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CC=C(C=C4)O)N.O=C(O)C(F)(F)F.[x]

C145H246N48O31S·xC2HF3O2

3189.87 (free base)

[1]Liu H, et al. A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. J Immunol. 2021 Sep 15;207 (6) :1652-1661. |[2]Gao, C.J, et al. IKK beta-targeting short peptides and application thereof in inflammatory diseases. 2020-11-24.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10966A/Tat-IKIP-46-60-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported