TAT-PDHPS1

TAT-PDHPS1 is a YAP inhibitor composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), leading to increased YAP phosphorylation, which inactivates YAP and suppresses the expression of its downstream target genes. TAT-PDHPS1 is potentially useful in ovarian cancer research[1].

12352209

YAP

Stem Cell/Wnt

Cancer

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C156H280N62O45

3744.28

[1]Pan X, et al. Peptide PDHPS1 Inhibits Ovarian Cancer Growth through Disrupting YAP Signaling. Mol Cancer Ther. 2022 Jul 5;21 (7) :1160-1170.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11219/

Peptides

No Development Reported