TAT-QFNP12 (acetaat)

TAT-QFNP12 acetate is a peptide that blocks the NDRG2-PPM1A binding and reduces Smad2/3 phosphorylation, decreases astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH) [1].

12352209

MMP; TGF-beta/Smad

Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

Neurological Disease

95.90

CC(O)=O.O=C([C@@H](N)CC1=CC=C(O)C=C1)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCC(O)=O)=O)CC(C)C)=O)CC2=CC=C(O)C=C2)=O)CCCCN)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)C(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O.[x]

C130H225N47O35.xC2H4O2

3006.47 (free base)

[1]Feng D, et al. Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage. Sci Adv. 2022 Sep 30;8 (39) :eabq2423.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10359A/TAT-QFNP12-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported