TAU Antilichaam

The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3) . Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4) .

4137

P10636

NP_058519

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

TAU antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

TAU antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TAU antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.

TAU

Cat. No. 1463 - Rat Brain Tissue Lysate

Microtubule-associated protein tau

Homo sapiens

Dotti CG, Banker GA, and Binder LI. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience 1987; 23:121-30.

Hanger DP, Brion JP, Gallo JM, et al. Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated. Biochem. J. 1991; 275:99–104.

Rocher AB, Crimins JL, Amatrudo JM, et al. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp. Neurol. 2010; 223:385–93.

Galimberti D and Scarpini E. Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration. IInt. J. Clin. Exp. Med. 2010; 3:129-43.

Microtubial-associated protein tau, MAPT, MAPTL, DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103

ELISA, WB, IHC-P

294862261

Liquid