Tau (fosfo Thr181) Antilichaam

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

4137

P10636

NP_001116538.1

Human, Mouse, Rat

Tau (Phospho-Thr181) antibody was raised against a peptide sequence around phosphorylation site of threonine 181 (P-K-T (p) -P-P) derived from Human Tau.

Unconjugated

Primary Antibodies

Phospho-Specific, Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

48, 62, 78 kDa

This antibody detects endogenous level of Tau only when phosphorylated at threonine 181.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

MAPT

Microtubule-associated protein tau

Homo sapiens

Puig B, et al. (2005) Acta Neuropathol (Berl) . 110 (3) : 261-268. Perez M, et al. (2005) Neuroscience. 130 (2) : 339-347. Fellgiebel A, et al. (2004) Biol Psychiatry. 56 (4) : 279-283. del C Alonso A, et al. (2004) J Biol Chem. 279 (33) : 34873-34881.

TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, PTP2C, SHPTP2, MAPT, MTAPT, Neurofibrillary tangle protein, PHF-tau

WB, IHC

178557734

Liquid