TBX1 Antilichaam - middengebied: Biotine (ARP33398 P050-Biotine)

T-box 1

DGS, TGA, VCF, CAFS, CTHM, DGCR, DORV, VCFS, TBX1C, CATCH22

6899

O43435

NP_542377

Human, Mouse, Rat, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human TBX1

TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS) /velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS) /velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

TERF2; TERF1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Guinea Pig: 85%; Horse: 77%; Human: 100%; Mouse: 77%; Rabbit: 85%; Rat: 85%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

43kDa

Ma, G., (2007) Neurosci. Lett. 425 (3), 146-150

Wet Ice

398

TBX1

TBX1

Rabbit

T-box transcription factor TBX1

NM_080646

PVASPTQPSGTEKGGHVLKDKEVKAETSRNTPEREVELLRDAGGCVNLGL