TCC52 Antilichaam

TCC52 Antibody: Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.

25853

Q5T6F0

NP_056212

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

TCC52 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (87%)

TCC52 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TCC52 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgY

DCAF12

Cat. No. 17-010 - HEK293 Cell Slide

DDB1 and CUL4 associated factor 12

Homo sapiens

Scanlan M, Simpson A, and Old L. The cancer/testis genes: review, standardization, and commentary. Cancer Immun.2004; 4:1-15.

Xia L, Li Y, Yang D, et al. Identification of new centrosome proteins by autoimmune patient sera. Sci. China C. Life Sci.2007; 50:194-202.

Li S, Hu X, Cui S, et al. Novel centrosome protein, TCC52, is a cancer-testis antigen. Cancer Sci.2008; 11:2274-9.

TCC52 Antibody: CT102, TCC52, WDR40A, KIAA1892, DDB1- and CUL4-associated factor 12, Centrosome-related protein TCC52

ELISA, WB, ICC

22218619

Liquid