TCEB1-antilichaam

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

6921

Q15369

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-112 of human TCEB1 (NP_001191791.1) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 12kDa

IgG

WB: 1:500 - 1:2000

TCEB1

PC-3

MCF7

HepG2

Mouse liver

Mouse lung

Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

Homo sapiens

TCEB1, SIII, eloC

WB

Liquid