TCTN1 Antilichaam

TCTN1 Antibody: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh) -mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

79600

Q2MV58

NP_001076007

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

TCTN1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 - Mouse Kidney Tissue Lysate

1 mg/mL

TCTN1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TCTN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TCTN1

Cat. No. 10-401 - Human Kidney Tissue Slide

Tectonic family member 1

Homo sapiens

Reiter JF and Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathwy required for both activation and inhibition. Genes Dev.2006; 20:22-7.

TCTN1 Antibody: TECT1, JBTS13, TECT1, UNQ9369/PRO34160, Tectonic-1

ELISA, WB, IHC-P, IF

130978359

Liquid