TDG Antilichaam

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.

6996

Q13569

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 141-410 of human TDG (NP_003202.3) .

Unconjugated

Primary Antibodies

Other

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

TDG

G/T mismatch-specific thymine DNA glycosylase

Homo sapiens

G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, hTDG, TDG

WB, IF

Liquid