TDGF1 Antilichaam

TDGF1 Antibody: Teratocarcinoma-derived growth factor 1 (TDGF1 or Cripto) is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and cellular transformation. It is first expressed in the forming mesoderm during gastrulation but later in development the expression is restricted to the truncus arteriosus of the developing heart. This suggests that TDGF1 mediates the progression of epiblastic cells that give rise to the mesoderm. TDGF1 overexpression is characteristic of human gastric and colorectal carcinomas.

6997

P13385

NP_003203

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

TDGF1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

TDGF1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TDGF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

21 kDa

IgG

TDGF1

Cat. No. 17-010 - HEK293 Cell Slide

Teratocarcinoma-derived growth factor 1

Homo sapiens

Brandt R, Normanno N, Gullick WJ, et al. Identification and biological characterization of an epidermal growth factor-related protein: Cripto-1. J. Biol. Chem. 1994; 269:17320-8.

Dono R, Scalera L, Pacifico F, et al. The murine Cripto gene: expression during mesoderm induction and early heart morphogenesis. Development 1993; 118:1157-68.

Parisi S, D'Andrea D, Lago CT, et al. Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J. Cell Biol. 2003; 163:303-14.

Xing PX, Hu XF, Pietersz GA, et al. Cripto: a novel target for antibody-based cancer immunotherapy. Cancer Res. 2004; 64:4018-23.

TDGF1 Antibody: CR, CRGF, CRIPTO, Teratocarcinoma-derived growth factor 1, Cripto-1 growth factor

ELISA, WB, IF

4507425

Liquid