TDP43 Antilichaam

TDP43 Antibody: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U) . TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

23435

Q13148

ABO32290

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

TDP43 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

TDP43 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TDP43 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.

TARDBP

Cat. No. 17-001 - HeLa Cell Slide

TAR DNA binding protein

Homo sapiens

Ou SH, Wu F, Garcia-Martinez LF, et al. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J. Virol.1995; 69:3584-96.

Buratti E, Dork T, Zuccato E, et al. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J.2001; 20:1774-84.

Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science2006; 314:42-3.

TDP43 Antibody: ALS10, TDP-43, TDP43, TAR DNA-binding protein 43

ELISA, WB, ICC, IF

130750552

Liquid