Tepotinib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Tepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
Unconjugated
White solid
-20°C
Beschrijving
Tepotinib Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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