TERF2 Antilichaam

The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1) . TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2) . TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3) . TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5) .

7014

Q15554

NP_005643

Human

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

TERF2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (92%)

TERF2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TERF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TERF2 antibody is human specific.

TERF2

Cat. No. 10-401 - Human Kidney Tissue Slide

Telomeric repeat binding factor 2

Homo sapiens

Broccoli D, Smogorzewska A, Chong L, et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 1997; 17:231-5.

Bilaud T, Brun C, Ancelin K, et al. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 1997; 17:236-9.

Van Steensel B and Smogorzewska A. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92:401-13.

Matsutani N, Yokozaki H, Tahara E, et al. Expression of TRF1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. Int. J. Oncol. 2001; 19:507-12.

TERF2 Antibody: TRF2, TRBF2, TRF2, Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2

ELISA, WB, IHC-P

429535832

Liquid