Terpestacine

Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity[1][2].

146436-22-8

12352211

HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Cancer

OC[C@@H](C)C1=C(C([C@@]2([C@@]1(C/C=C([C@H](CC/C(C)=C/CC/C(C)=C/C2)O)\C)[H])C)=O)O

C25H38O4

402.57

[1]Masi M, et al. Terpestacin, a toxin produced by Phoma exigua var. heteromorpha, the causal agent of a severe foliar disease of oleander (Nerium oleander L.) . Nat Prod Res. 2022 Mar;36 (5) :1253-1259.|[2]Jung HJ, et al. Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J Biol Chem. 2010 Apr 9;285 (15) :11584-95.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15497/

Natural Products

No Development Reported