Tersolisib (STX-478)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2883540-92-7
PI3K
PI3K/Akt/mTOR
C16H12F5N5O2
Tersolisib (STX-478) is a highly potent, mutant-selective, allosteric inhibitor of PI3Kα, that selectively targets prevalent mutant forms of PI3Kα. It demonstrates strong efficacy against common PI3Kα helical- and kinase-domain mutations, including the H1047R variant, with an IC50 value of 9.4 nmol/L. STX-478 exhibits 14-fold greater selectivity for mutant PI3Kα over the wild-type form. It spares metabolic dysfunction and improves therapeutic response in PI3Kα-Mutant Xenografts.
Beschrijving
Tersolisib (STX-478) Beschikbaar in 1 g. Bestel eenvoudig online met snelle levering.
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