TESPA1 Antilichaam

TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development (1) . TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species (2) . TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage (3) . TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus (1,4) .

9840

A2RU30

NP_001129502

Human

Unconjugated

Primary Antibodies

Immunology

TESPA1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (100%)

TESPA1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TESPA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TESPA1 antibody is human specific. At least three isoforms TESPA1 are known to exist.

TESPA1

Cat. No. 17-002 - A-431 Cell Slide

Thymocyte expressed, positive selection associated 1

Homo sapiens

Wang D, Zheng M, Lei L, et al. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat. Immunol. 2012; 13:560-8.

Matsuzaki H, Fujimoto T, Ota T, et al. Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes. FEBS Open Bio. 2012; 2:255-9.

Matsuzaki H, Fujimoto T, Tanaka M, et al. Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux. Biochem. Biophys. Res. Commun. 2013; 433:322-6.

Fujimoto T, Matsuzaki H, Tanaka M, et al. Tespa1 protein is phosphorylated in response to store-operated calcium entry. Biochem. Biophys. Res. Commun. 2013; 434:162-5.

TESPA1 Antibody: HSPC257, KIAA0748, HSPC257, Protein TESPA1, Thymocyte-expressed positive selection-associated protein 1

ELISA, WB, ICC, IF

209862861

Liquid