TET1 Antilichaam

TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t (10;11) (q22; q23) (1) . It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2) . TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3) . Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4) .

80312

Q8NFU7

NP_085128

Human, Mouse, Rat

7733

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

TET1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 – Mouse Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (88%)

TET1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TET1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.

Human TET1 has one isoform (2136aa, 235kD) . Mouse TET1 has one isoform (2007aa, 219kD) and Rat TET1 also has one isoform (2033aa, 223kD) . 7733 can detect human, mouse and rat.

TET1

Cat. No. 11-701 - Human Testis Tissue Slide

Tet methylcytosine dioxygenase 1

Homo sapiens

Lorsbach, et al. Leukemia 2003; 17:637-41.

Tahilani , et al. Science 2009; 324:930-5.

Neves-Costa, et al. Immunol. 2013; 54:264-70.

Sun, et al. Sci. USA 2013; 110:9920-5.

26917720

TET1 Antibody: LCX, CXXC6, bA119F7.1, KIAA1676, LCX, Methylcytosine dioxygenase TET1, CXXC-type zinc finger protein 6

ELISA, WB, IHC-P, IF

156139122

Liquid