TET2 Antilichaam

TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms (1), and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia (2) . Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

54790

Q6N021

NP_001120680

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

TET2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

TET2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TET2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TET2 antibody is human and mouse reactive. At least two isoforms of TET2 are known to exist; this antibody will detect the larger isoforms. This antibody is predicted to not cross-react with TET1 and TET3.

TET2

Tet methylcytosine dioxygenase 2

Homo sapiens

Tefferi A, Levine RL, Lim KH, et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIPL1-PDGFRA correlates. Leukemia 2009; 23:900-4.

Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood 2011; 115:2003-7.

TET2 Antibody: MDS, KIAA1546, Nbla00191, Methylcytosine dioxygenase TET2

ELISA, WB

187761317

Liquid