TET2 Polyklonale Antilichaam, PE Vervoeging

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC) . Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

MDS; KIAA1546; Methylcytosine dioxygenase TET2; TET2; Nbla00191

54790

Q6N021

Human, Mouse, Rat

1165-1215/2002

TET2

PE

KLH conjugated synthetic peptide derived from human TET2

IF, Flow-Cyt

Purified by Protein A.

496,564nm/578nm

1µg/µl

IF (IF=1:50-200), Flow-Cyt (Flow-Cyt=2ug/Test)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

54790