Tetrabenazinemetaboliet
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM) [1]. Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders[1].
924854-60-4
(-) -β-Dihydrotetrabenazine; (-) -β-HTBZ
12352005
Drug Metabolite; Monoamine Transporter
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Neuroscience-Neurodegeneration
Neurological Disease
10 mM in DMSO
O[C@H]([C@H](CC(C)C)C1)C[C@@]2([H])N1CCC3=C2C=C(OC)C(OC)=C3
C19H29NO3
319.44
[1]Yao Z, et al. Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors. Eur J Med Chem. 2011 May;46 (5) :1841-8.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-G0025/
Reference compound1
No Development Reported
Beschrijving
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high
Specificaties
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