Tetrachloorhydrochinon

Tetrachlorohydroquinone (TCHQ) is a metabolite of Pentachlorophenol. Tetrachlorohydroquinone induces reactive oxidant stress (ROS), inhibits apoptosis and induces necrosis in primary mouse splenocytes. Tetrachlorohydroquinone increases DNA lesions and induces oxidative stress in rodents[1].

87-87-6

TCHQ; Tetrachloroquinol

12352005

H302, H315, H319

Apoptosis; Drug Metabolite; Necroptosis; Reactive Oxygen Species (ROS)

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Metabolism-sugar/lipid metabolism

Cancer; Metabolic Disease

10mM

98.45

DMSO : 200 mg/mL (ultrasonic)

C1(=C(C(=C(C(=C1Cl)O)Cl)Cl)O)Cl

C6H2Cl4O2

247.89

H302, H315, H319

[1]Chen HM, et al. The pentachlorophenol metabolite tetrachlorohydroquinone induces massive ROS and prolonged p-ERK expression in splenocytes, leading to inhibition of apoptosis and necrotic cell death. PLoS One. 2014 Feb 26;9 (2) :e89483.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W144308/Tetrachlorohydroquinone-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported