Tetracosactide (acetaat)

Tetracosactide acetate (Tetracosactrin acetate) is the acetate salt form of Tetracosactide. Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis[1][3].

60189-34-6

Tetracosactrin (acetate) ; ACTH (1–24) (acetate)

12352209

H317, H332, H334

CRFR; Melanocortin Receptor

GPCR/G Protein; Neuronal Signaling

Metabolism-protein/nucleotide metabolism

Inflammation/Immunology; Neurological Disease

99.35

H2O : ≥ 100 mg/mL

CC(O)=O.O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N7[C@@H](CCC7)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC8=CC=C(C=C8)O)C(N9[C@@H](CCC9)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

C136H210N40O31S.xC2H4O2

H317, H332, H334

[1]Francesco Iuliano, et al. Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation. 2018 Nov 29;132 (1) .|[2]Kertmen H, et al., Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord. Arch Med Sci. 2018 Oct;14 (6) :1459-1470.|[3]Haslach EM, et al., Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs) . J Med Chem. 2014 Jun 12;57 (11) :4615-28.|[4]Lindhe O, et al., Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue-slice culture. Environ Health Perspect. 2001 Feb;109 (2) :105-10.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-P0060A/Tetracosactide-acetate-SDS-MedChemExpress.pdf

Peptides

Launched

MC4R