Tetracycline-d6-1

Tetracycline-d6-1 is deuterated labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections[1].

12352005

Antibiotic; Bacterial; Isotope-Labeled Compounds

Anti-infection; Others

COVID-19-immunoregulation

Infection

10 mM in DMSO

[H][C@]12C[C@]3([C@@H](C(C(C(N)=O)=C([C@]3(C(C1=C(C4=C([C@]2(O)C)C=CC=C4O)O)=O)O)O)=O)N(C([2H])([2H])[2H])C([2H])([2H])[2H])[H]

C22H18D6N2O8

450.47

[1]Chopra I, et al. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65 (2) :232-60.|[2]Bowdre JH, et al. Antibiotic efficacy against Vibrio vulnificus in the mouse: superiority of tetracycline. J Pharmacol Exp Ther. 1983 Jun;225 (3) :595-8.|[3]Forloni G, et al. Anti-amyloidogenic activity of tetracyclines: studies in vitro. FEBS Lett. 2001 Jan 5;487 (3) :404-7.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0107S2/

Isotope-Labeled Compounds

No Development Reported