Tetrahydropapaverine (hydrochloride)

Tetrahydropapaverine hydrochloride is a tetrahydroisoquinoline (TIQ) compound with inhibitory effects on tryptophan hydroxylase (TPH) (IC50 = 5.7 μM) . Tetrahydropapaverine hydrochloride decreases intracellular serotonin content in murine mastocytoma P815 cells, with an IC50 value of 6.2 μM. Tetrahydropapaverine hydrochloride can be used for studies on potential neurotoxicity in monoaminergic neurons[1][2].

6429-04-5

12352005

H302

Tryptophan Hydroxylase

Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Neurological Disease

99.84

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

COC1=CC2=C(C=C1OC)CCNC2CC3=CC=C(OC)C(OC)=C3.[H]Cl

C20H26ClNO4

379.88

H302

[1]Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773 (1-2) :108-16.|[2]Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75 (16) :1949-57.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-N0137/Tetrahydropapaverine-hydrochloride-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported