Tetrahydropapaveroline (hydrobromide)

Tetrahydropapaveroline (Norlaudanosoline) hydrobromide, an isoquinoline alkaloid, is a condensation product of dopamine and dopaldehyde. Tetrahydropapaveroline hydrobromide inhibits [3H]DA uptake with a Ki of 41 μM. Tetrahydropapaveroline hydrobromide can be used for the study of Parkinson's disease and/or alcohol addiction[1][2].

16659-88-4

Norlaudanosoline (hydrobromide)

12352005

H302, H315, H319, H335

Dopamine Receptor

GPCR/G Protein; Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

99.82

OC1=CC=C(CC2NCCC3=CC(O)=C(C=C32)O)C=C1O.Br

C16H18BrNO4

368.22

H302, H315, H319, H335

[1]Zhu W, Mantione KJ, Shen L, Lee B, Stefano GB. Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction. Cell Mol Neurobiol. 2006;26 (4-6) :1037-1045. |[2]Okada T, et al. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res. 1998 Jan;30 (1) :87-90.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-W206168/Tetrahydropapaveroline-hydrobromide-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported