Tetrahydrozoline-d4 (hydrochloride)

Tetrahydrozoline-d4 (hydrochloride) is the deuterium labeled Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion[1][2].

1246814-66-3

Tetryzoline-d4 (hydrochloride)

12352005

Adrenergic Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Cardiovascular Disease; Endocrinology

99.80

10 mM in DMSO

[2H]C1([2H])C([2H])([2H])NC(C2C3=CC=CC=C3CCC2)=N1.Cl

C13H13D4ClN2

240.77

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190 (40) :E1208.|[3]Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS) . Methods Mol Biol. 2010;603:501-8.|[4]Danuta Nowakowska, et al. In vitro effects of vasoconstrictive retraction agents on primary human gingival fibroblasts. Exp Ther Med. 2020 Mar; 19 (3) : 2037-2044.

Blue Ice

-20°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-B0556AS/Tetrahydrozoline-d4-hydrochloride-SDS-MedChemExpress.pdf

Isotope-Labeled Compounds

No Development Reported