Tetrahydrozoline (nitraat)

Tetrahydrozoline (Tetryzoline) nitrate , a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion[1][2].

118201-38-0

Tetryzoline (nitrate)

12352005

Adrenergic Receptor

GPCR/G Protein; Neuronal Signaling

Metabolism-protein/nucleotide metabolism

Metabolic Disease; Cardiovascular Disease

10 mM in DMSO

[O-][N+]([O-])=O.C1(C2CCCC3=C2C=CC=C3)=NCCN1

C13H16N3O3-

262.28

[1]E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190 (40) :E1208.|[2]Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS) . Methods Mol Biol. 2010;603:501-8. |[3]Danuta Nowakowska, et al. In vitro effects of vasoconstrictive retraction agents on primary human gingival fibroblasts. Exp Ther Med. 2020 Mar; 19 (3) : 2037-2044.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0556B/

Reference compound1

Launched