Tetramethylpyrazine nitrone

Tetramethylpyrazine nitrone is a nitrone derivative of tetramethylpyrazine. Tetramethylpyrazine nitrone is an active ingredient from Ligusticum wallichii Franchat. Tetramethylpyrazine nitrone is a potent scavenger of free radicals with neuroprotective activitys in both rat and monkey models of ischemis stroke. Tetramethylpyrazine nitrone can suppress over-expression of neuroinflammatory marker vimentin[1][2].

1083171-75-8

TBN

12352005

Drug Derivative

Others

COVID-19-immunoregulation

Inflammation/Immunology; Neurological Disease

CC1=C(C)N=C(C)C(/C=[N+](C(C)(C)C)\[O-])=N1

C12H19N3O

221.30

[1]Zhou, X., et al., (2023) . Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. Frontiers in pharmacology, 14, 1082602. |[2]Zhang, Z., et al., (2016) . Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Scientific reports, 6, 37148.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-202233/

Reference compound1

No Development Reported