Tetramisool

Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure[1][2].

5036-02-2

12352005

Parasite; PKA; Potassium Channel

Anti-infection; Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad

Neuroscience-Neuromodulation

Infection; Cardiovascular Disease

C12=NC(C3=CC=CC=C3)CN1CCS2

C11H12N2S

204.29

[1]Liu Q, et al. Tetramisole is a new IK1 channel agonist and exerts IK1 -dependent cardioprotective effects in rats. Pharmacol Res Perspect. 2022 Aug;10 (4) :e00992.|[2]Nowak LG, et al. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex. Subcell Biochem. 2015;76:239-81.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1194A/

Reference compound1

Launched

Inwardly rectifying potassium channel