TFE3 Antilichaam

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5') . Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

7030

P19532

NP_006512.2

Human, Mouse

TFE3 antibody was raised against a peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

70 kDa

This antibody detects endogenous levels of total TFE3 protein.

Western Blot: 1:500~1:1000

TFE3

Transcription factor binding to IGHM enhancer 3

Homo sapiens

Clark J., Lu Y. -J., Sidhar S. K., Parker C., Gill S., Oncogene 15:2233-2239 (1997) Weterman M. A. J., Wilbrink M., Proc. Natl. Acad. Sci. U. S. A. 93:15294-15298 (1996)

TFEA, RCCP2, RCCX1, bHLHe33, MAPTL, MTBT1, TAU, BHLHE33, TFEA

WB

8659574

Liquid