TFF3 Antilichaam

TFF3 Antibody: Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa.

7033

Q07654

NP_003217

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

TFF3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1320 - Human Colon Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (81%), Pig: (81%)

TFF3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TFF3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TFF3 antibody is predicted to not cross-react with other TFF family members.

TFF3

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Trefoil factor 3 (intestinal)

Homo sapiens

Podolsky DK, Lynch-Devaney K, Stow JL, et al. Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. J. Biol. Chem. 1993; 268:6694-702.

Gott P, Beck S, Machado JC, et al. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. Eur. J. Hum. Genet. 1996; 4:308-15.

Hernandez C, Santamatilde E, McCreath KJ, et al. Induction of trefoil factor TFF1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: implications for gastric mucosal healing. Br. J. Pharmacol. 2009; 156:262-72.

Thim L. Trefoil peptides: from structure to function. Cell Mol. Life Sci. 1997; 53:888-903.

TFF3 Antibody: ITF, P1B, TFI, ITF, Trefoil factor 3, Intestinal trefoil factor, hITF

ELISA, WB, IHC-P, ICC, IF

119629977

Liquid