TG2-IN-3h

TG2-IN-3h (Compound 3h) is a transglutaminase (TG2) inhibitor (hTG2: IC50 = 6nM) . TG2-IN-3h inhibits endothelial cell migration and angiogenesis. TG2-IN-3h alleviates renal fibrosis in a mouse model of hypertensive nephropathy. TG2-IN-3h can be used in research on metabolic diseases such as hypertensive nephropathy and cardiovascular and cerebrovascular diseases such as pathological angiogenesis[1].

1592640-75-9

12352005

Glutaminase

Metabolic Enzyme/Protease

Cardiovascular Disease; Metabolic Disease

O=C(C=C)NCC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=CC=3C2=CC=CC3N(C)C

C21H26N4O4S

430.52

[1]Badarau E, et al. Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol. 2015 Oct 22;22 (10) :1347-61.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180322/

Reference compound1

No Development Reported