TGF beta 3 Recombinant eiwit

The three mammalian isoforms of TGF-β , TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

7043

P10600

NP_003230.1

Recombinant Proteins

E. coli

Other

Room Temp

The lyophilized TGF beta 3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TGF beta 3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TGF beta 3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Transforming growth factor, beta 3

Homo sapiens

ARVD, RNHF, ARVD1, TGF-beta3, Transforming growth factor beta-3, TGF-beta-3

Human

4507465

Lyophilized