TGF beta Receptor II (fosfo Ser225/250) Antilichaam

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.

7048

P37173

NP_003233.4

Human, Mouse, Rat

TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p) -D-I) derived from Human TGF beta Receptor II.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

64 kDa

IgG

The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250.

TGFBR2

Transforming growth factor, beta receptor II (70/80kDa)

Homo sapiens

RC Tripathi, Invest. Ophthalmol. Vis. Sci., Jan 1993; 34: 260.

N Chegini, Endocrinology, Jul 1994; 135: 439.

GW Mulheron, Endocrinology, Dec 1992; 131: 2609

TGF-betaR2, TGFR2, kinase TGF-beta-R2

IHC

67782324

Liquid