TGFBR2 Antilichaam - N-terminaal gebied: Biotine (ARP44743 T100-Biotine)

Transforming growth factor, beta receptor II (70/80kDa)

AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII

7048

P37173

NP_003233

Human, Mouse, Rat, Cow, Goat, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human TGFBR2

TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

TRAF4; NRP1; NRP2; TGFB1; TERT; PEG10; ENG; GOPC; IQGAP1; UBC; RCVRN; PDGFRA; APP; TGFBR1; MAP3K7; PAK1; OCLN; SMAD7; CDC42; Hsp90aa1; KCNK18; FBXO34; PPP1R16B; OXSR1; ARHGEF6; TRAF6; TSC22D1; SMURF1; OSR1; TCTEX1D4; SNX6; TSSK1B; TGFBRAP1; TRAP1; STRAP

Biotin

Polyclonal Antibody

WB

TGFBR2 is strongly supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 93%; Goat: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

62kDa

Song, K., (2006) J. Biol. Chem. 281 (12), 7765-7774

Wet Ice

567

TGFBR2

TGFBR2

Rabbit

TGF-beta receptor type-2

NM_003242

MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRT